Engineered Extracellular Matrix Scaffolds

Facilitate Stem Cell Recruitment, Tissue Regeneration

Studies have shown that implanted extracellular matrix scaffolds (such as processed amniotic fluid and placental tissue) with inductive niches can facilitate stem cell recruitment and differentiation of host cells, thereby enhancing regeneration of several cell and tissue types. These extracellular matrix scaffolds provide cells with “guidance cues” for directional migration and spacial organization resulting in versatile, adaptable and functional integration.

1. Skeletal Muscle Regeneration: “The presence of acetylcholine receptor (AChR) (α-BTX+) clusters on the neo-muscle fibers (desmin+), indicated that ECM-C promoted nerve migration and integration within neo-muscle fibers.”

2. Nerve Regeneration: “Statistically, the muscle fiber size of ECM-C neo-nerve groups was significantly larger than that of the control group.”

3. Vascular Regeneration: “Staining of the luminal surface of ECM-C neo-artery and native artery confirmed complete coverage by CD31 positive cells with cobblestone-like morphology and oriented parallel to the direction of blood flow.”

“Recruitment of endogenous cells for tissue formation, also called in-situ tissue regeneration, represents a promising strategy to restore the lost tissues.”