Harvard Review: Growth factor delivery–based tissue engineering developments
The systems and similar Stem Cell Recruitment™ products reviewed that can recruit cells into a scaffold, tend to be versatile and could be used for many different applications. “For example, systems that can recruit cells into a scaffold, programme the cells appropriately and stimulate cells to leave the scaffolds may allow one to bypass the ex vivo culture and manipulation common to current cell therapies.”
Tissue engineered systems like acellular amniotic fluid or amniotic tissue can be functionalized to recruit specific subsets of cells, where the cells are programmed to execute a specific task after leaving the material that can be to maintain, regenerate or even to destroy a particular tissue or subset of cells at the site of inflammation and injury within the soft tissue or joint.
This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives are discussed. Recent progress highlights the importance of materials science and engineering in growth factor delivery approaches to regenerative medicine.